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Tirzepatide (Zepbound brand) is used for weight loss, to help lose weight and keep weight off. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time. Tirzepatide is a once-weekly injection given under the skin using a pen (autoinjector).
Zepbound (tirzepatide) is FDA-approved for weight loss in adults with obesity or who are overweight and have weight-related medical problems. Zepbound helps you to lose weight and maintain weight loss and should be combined with diet and exercise.
Tirzepatide (Mounjaro brand) is used for type 2 diabetes to help improve blood sugar levels. In type 2 diabetes, tirzepatide decreases blood sugar levels by helping release insulin when blood sugar levels are high, lowering the amount of sugar the liver makes, and slowing food movement through the intestines. Mounjaro should be used together with diet and exercise.
Mounjaro (tirzepatide) is FDA-approved to treat adults with type 2 diabetes and should be used together with diet and exercise. It can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors
It is not known if tirzepatide can be used in people who have had pancreatitis. Tirzepatide should not be used in people who have type 1 diabetes.
Mounjaro and Zepbound both contain the same active ingredient, tirzepatide and are made by Eli Lilly and Company. They are both available as single-dose pens in the same strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per 0.5 mL, and Zepbound is available as single-dose vials 2.5 mg/0.5 ml and 5 mg/0.5 ml.
Normally, when we eat, natural hormones called GIP and GLP-1 are released by the gut. These hormones increase insulin release, suppress appetite, slow gastric emptying, and increase the feeling of fullness. Tirzeptide works like our natural hormones GIP and GLP-1 by activating the GIP and GLP-1 receptors.
Tirzepatide is a GIP and GLP-1 receptor agonist. Tirzepatide works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors.
Patients on Zepbound (tirzepatide) 5mg weekly lost 16.1 kg (35.5 lb) on average after 72 weeks. For Zepbound's 10mg weekly dose, the average weight loss was 22.2 kg (48.9 lb), and for Zepbound's 15mg weekly dose average weight loss was 23.6 kg (52.0 lb) over 72 weeks. Patients who used a placebo lost 2.4 kg (5.3 lb) over the 72 weeks. These results are from the clinical trial SURMOUNT-1, NCT04184622. Individual results may vary.
The most common tirzepatide side effects include abdominal pain, burping, constipation, diarrhea, dyspepsia, fatigue, gastroesophageal reflux disease, hair loss, hypersensitivity reactions, injection site reactions, nausea, and vomiting, which affects 5% or more patients.
Serious tirzepatide side effectsSerious tirzepatide side effects include severe stomach problems, acute kidney damage, gallbladder disease, inflamed pancreas (acute pancreatitis), serious allergic reactions, low blood sugar levels (hypoglycemia), diabetic retinopathy issues in type 2 diabetics, suicidal behavior or thoughts, and food or liquid getting into the lungs during anesthesia or deep sedation.
Stop using this medicine and get emergency medical help if you have:
signs of an allergic reaction: hives; difficulty breathing; feeling light-headed; swelling of your face, lips, tongue, or throat; or pancreatitis with symptoms of severe pain in your upper stomach spreading to your back, nausea, and vomiting.Call your doctor at once if you have:
severe stomach problems; eye side effects or vision changes, including blurry vision or blurred vision; signs of a thyroid tumor symptoms may include swelling or a lump in your neck, trouble swallowing, a hoarse voice, or if you feel short of breath; gallbladder problem with symptoms including chalky-colored stools, stomach pain after eating, nausea, heartburn, bloating, and severe upper stomach pain that may spread to your back; low blood sugar symptoms may include headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery or kidney problems with little or no urination, swelling in your feet or ankles, feeling tired or short of breath.Tirzepatide may cause thyroid C-cell tumors. It is important to tell your doctor if you have a personal or your family has a history of thyroid cancer or a condition called Multiple Endocrine Neoplasia (MEN) syndrome. This is a syndrome that causes tumors to develop on endocrine glands. If you experience any of these symptoms: lump or swelling in your neck, difficulty in swallowing, hoarseness, or shortness of breath, then you should call your doctor immediately.
Keep all appointments with your doctor, health professionals, and the laboratory. Your doctor may order certain tests to check your body's response to this medicine.
You should follow the directions on your prescription label carefully and ask your pharmacist or doctor to explain any part you do not understand. It is important to use this medicine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Tirzepatide is injected under the skin (subcutaneously) using a pre-filled pen or a single-dose vial with a syringe. Caregivers or patients should be trained on proper injection techniques. When using single-dose vials, a 1 mL syringe capable of measuring a 0.5 mL dose must be used for dose administration.
It is usually given
once a week. can be given with or without meals at any time of the day. may be injected into the thigh, abdomen, or upper arm. You should rotate injection sites with each dose.Your doctor will probably start you on a low dose, which may be gradually increased, but not more than once every 4 weeks.
You may change the day of the week you use tirzepatide as long as there are at least three days between doses.
You may administer insulin in the same area as tirzepatide, but they should not be given right next to each other. Insulin and tirzepatide should be given as separate injections and not be mixed in the same injection.
Mounjaro controls type 2 diabetes but does not cure it. It may take four weeks or longer before you see the full benefit of this medicine. Continue to take this medicine even if you feel well. Do not stop taking this medicine without talking to your doctor.
Initial dose: 2.5 mg under the skin (subcutaneously) once a week.
After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week.
Further dose increases: After at least 4 weeks on the current dose the dosage may be increased in 2.5 mg increments.
Recommended maintenance dose: 5 mg, 10 mg, or 15 mg injected subcutaneously once weekly.
Maximum dose: 15 mg subcutaneously once a week.
Usual Mounjaro Dose for Diabetes Type 2 (Adult)Initial dose: 2.5 mg under the skin (subcutaneously) once a week.
After 4 weeks: The dosage should be increased to 5 mg subcutaneously once a week.
If additional glycemic control is needed: The dosage should be increased in 2.5 mg increments after at least 4 weeks on the current dose.
Maximum dose: 15 mg subcutaneously once a week.
Comments: The 2.5 mg dosage is for starting of treatment and is not intended for glycemic control. The day of weekly administration can be changed, if necessary, as long as the time between the 2 doses is at least 3 days (72 hours).